HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Ethylpiperazin-1-yl)propan-1-amine → 2-{5-Chloro-2-[3-(4-ethylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid methylamide tri-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Ethylpiperazin-1-yl)propan-1-amine | HCID 3149267 | — |
| Reactant | 2-(5-chloro-2-((3-(4-methylpiperazin-1-yl)propyl)amino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride | HCID 68856073 | — |
| Reactant | 2-(2,5-Dichloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid methylamide | HCID 86625382 | — |
| Product | 2-{5-Chloro-2-[3-(4-ethylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid methylamide tri-hydrochloride | HCID 68854840 | — |
Reaction Steps
Using the method of 2-{5-chloro-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride, the title compound is synthesized from 2-(2,5-dichloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid methylamide and 3-(4-ethylpiperazin-1-yl)-propylamine and isolated as a yellow solid. ES+(m/z) 473 (35Cl) and 475 (37Cl) [M(free base)+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547691B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-bcf2d9cb4a6f4c63b05120cdf9f46ea4 |
| Source note | uspto-grants-2009_06 |