HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Piperidineethanamine, 2,2,6,6-tetramethyl- → 2-{5-Bromo-2-[2-(2,2,6,6-tetramethylpiperidin-4-yl)-ethylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide di-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Piperidineethanamine, 2,2,6,6-tetramethyl- | HCID 12567367 | — |
| Reactant | 2-(5-chloro-2-((3-(4-methylpiperazin-1-yl)propyl)amino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride | HCID 68856073 | — |
| Reactant | 2-(5-Bromo-2-chloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide | HCID 86625343 | — |
| Product | 2-{5-Bromo-2-[2-(2,2,6,6-tetramethylpiperidin-4-yl)-ethylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide di-hydrochloride | HCID 68857114 | — |
Reaction Steps
Using the method of 2-{5-chloro-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride, the title compound is synthesized from 2-(5-bromo-2-chloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide and 2-(2,2,6,6-tetramethyl-piperidin-4-yl)-ethylamine and isolated as a yellow solid. ES+(m/z) 556 (79Br) and 558 (81Br) [M(free base)+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547691B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-b53a868552964be880dbbf53fa5b89b4 |
| Source note | uspto-grants-2009_06 |