tert-Butyl 4-(2-aminoethyl)piperidine-1-carboxylate → HCID 68857070, compound

HRID 1986294Notes

Reaction equation

HRID 1986294 reaction equation
C1(NC(C2C3C=C(C4C(Br)=CN=C([NH:23][CH2:24][CH2:25][CH:26]5[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]5)N=4)SC=3C=CC=2)=O)CC1.Cl[C:33]1[N:38]=[C:37]([C:39]2[S:43][C:42]3[CH:44]=[C:45]([C:48]([N:50]4[CH2:55][CH2:54][O:53][CH2:52][CH2:51]4)=[O:49])[CH:46]=[CH:47][C:41]=3[CH:40]=2)[C:36]([CH3:56])=[CH:35][N:34]=1.C(OC(N1CCC(CCN)CC1)=O)(C)(C)C>>[CH3:56][C:36]1[C:37]([C:39]2[S:43][C:42]3[CH:44]=[C:45]([C:48]([N:50]4[CH2:55][CH2:54][O:53][CH2:52][CH2:51]4)=[O:49])[CH:46]=[CH:47][C:41]=3[CH:40]=2)=[N:38][C:33]([NH:23][CH2:24][CH2:25][CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[N:34][CH:35]=1

Participants

4

Reactant 3

HCID 1514258tert-Butyl 4-(2-aminoethyl)piperidine-1-carboxylateHCID 68855973HCID 68855973, compoundHCID 86625386HCID 86625386, compound

Product 1

HCID 68857070HCID 68857070, compound

Procedure

Using the method of 2-[5-bromo-2-(2-piperidin-4-ylethylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid cyclopropylamide, the title compound is synthesized from [2-(2-chloro5-methylpyrimidin-4-yl)-benzo[b]thiophen-6-yl]-morpholin-4-yl-methanone and 4-(2-aminoethyl)-piperidine-1-carboxylic acid tert-butyl ester and isolated as a yellow solid. ES+(m/z) 466 [M+H].

Workup

  1. customisolated as a yellow solid

Sources & evidence

ORD record
ord-dd874f8fce3c43308df498abf6ff3253
Source dataset
uspto-grants-2009_06
Patent number
US07547691B2

Reaction notes

Loading…