HuagongsheHuagongshe Chemistry Print Report · For research reference only
[4-(Benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine → [4-(6-Bromobenzo[b]thiophen-2-yl)-5-chloropyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [4-(Benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine | HCID 57720607 | — |
| Reactant | 4-(6-Bromobenzo[b]thiophen-2-yl)-2,5-dichloropyrimidine | HCID 86625387 | — |
| Product | [4-(6-Bromobenzo[b]thiophen-2-yl)-5-chloropyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride | HCID 68902280 | — |
Reaction Steps
Using the method of [4-(benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine, the title compound is synthesized from 4-(6-bromobenzo[b]thiophen-2-yl)-2,5-dichloropyrimidine and isolated as a light orange solid. ES+(m/z) 480 (35C1, 79Br), 482 ([37Cl, 79Br] and [35Cl, 81Br]) and 484 (37Cl, 81Br) [M(free base)+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547691B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-4fa83df309c04a618103a4f4e9e10832 |
| Source note | uspto-grants-2009_06 |