2-{5-Chloro-2-[2-(1-methylpiperidin-4-yl)-ethylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid amide di-hydrochloride → 2-{5-Methyl-2-[3-(1-methylpiperidin-4-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid amide di-hydrochloride

HRID 1986311Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1986311
[ClH:1].Cl.[Cl:3][C:4]1C(C2SC3C=CC=C(C(N)=O)C=3C=2)=NC(NCCC2CCN(C)CC2)=NC=1.[CH3:32][C:33]1[C:34]([C:49]2[S:53][C:52]3[CH:54]=[CH:55][CH:56]=[C:57]([C:58]([NH2:60])=[O:59])[C:51]=3[CH:50]=2)=[N:35][C:36]([NH:39][CH2:40][CH2:41][CH2:42][CH:43]2[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]2)=[N:37][CH:38]=1>>[ClH:3].[ClH:1].[CH3:32][C:33]1[C:34]([C:49]2[S:53][C:52]3[CH:54]=[CH:55][CH:56]=[C:57]([C:58]([NH2:60])=[O:59])[C:51]=3[CH:50]=2)=[N:35][C:36]([NH:39][CH2:40][CH2:41][CH2:42][CH:43]2[CH2:48][CH2:47][N:46]([CH3:4])[CH2:45][CH2:44]2)=[N:37][CH:38]=1

Komponenten

3

Edukt 2

HCID 688560452-{5-Chloro-2-[2-(1-methylpiperidin-4-yl)-ethylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid amide di-hydrochlorideHCID 689059082-[5-Methyl-2-(3-piperidin-4-ylpropylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid amide

Produkt 1

HCID 689014552-{5-Methyl-2-[3-(1-methylpiperidin-4-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid amide di-hydrochloride

Versuchsvorschrift

Using the method of 2-{5-chloro-2-[2-(1-methylpiperidin-4-yl)-ethylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid amide di-hydrochloride, the title compound is synthesized from 2-[5-methyl-2-(3-piperidin-4-ylpropylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid amide and isolated as a yellow solid. ES+(m/z) 424 [M(free base)+H].

Aufarbeitung

  1. customisolated as a yellow solid

Quellen und Nachweise

ORD-Eintrag
ord-6198a405cb414bdcb091a7ccb22a8d9a
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07547691B2

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