HCID 68855943, compound → HCID 68856831, compound

HRID 1986338Notes

Reaction equation

[ClH:1].Cl.[Cl:3][C:4]1C(C2SC3C=CC=C(C(N)=O)C=3C=2)=NC(NCCC2CCN(C)CC2)=NC=1.[CH3:32][N:33]([CH3:61])[C:34]([C:36]1[CH:37]=[CH:38][C:39]2[CH:43]=[C:42]([C:44]3[C:49]([CH3:50])=[CH:48][N:47]=[C:46]([NH:51][CH2:52][CH2:53][CH:54]4[CH2:59][CH2:58][NH:57][CH2:56][CH2:55]4)[N:45]=3)[S:41][C:40]=2[CH:60]=1)=[O:35]>>[ClH:3].[ClH:1].[CH3:61][N:33]([CH3:32])[C:34]([C:36]1[CH:37]=[CH:38][C:39]2[CH:43]=[C:42]([C:44]3[C:49]([CH3:50])=[CH:48][N:47]=[C:46]([NH:51][CH2:52][CH2:53][CH:54]4[CH2:55][CH2:56][N:57]([CH3:4])[CH2:58][CH2:59]4)[N:45]=3)[S:41][C:40]=2[CH:60]=1)=[O:35]

Participants

Reactant 2

HCID 68855943HCID 68855943, compound

HCID 688560452-{5-Chloro-2-[2-(1-methylpiperidin-4-yl)-ethylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid amide di-hydrochloride

Product 1

HCID 68856831HCID 68856831, compound

Procedure

Using the method of 2-{5-chloro-2-[2-(1-methylpiperidin-4-yl)-ethylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid amide di-hydrochloride, the title compound is synthesized from crude product 2-[5-methyl-2-(2-piperidin-4-yl-ethylamino)-pyrimidin-4-yl]-benzo[b]thiophene-6-carboxylic acid dimethylamide and isolated as yellow foam (307 mg, 42% yield). ES+(m/z) 438 [M(free base)+H].

Sources & evidence

ORD record: ord-167d0ed09e874811b4c253691edc223b
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07547691B2

Reaction notes

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