4-Methylpiperazine-1-ethylamine → 2-{5-Methyl-2-[2-(4-methylpiperazin-1-yl)-ethylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride

HRID 1986341Notes

Reaction equation

HRID 1986341 reaction equation
[ClH:1].Cl.Cl.CNC(C1C2C=C(C3C(C)=CN=C(NCCCN4CCN(C)CC4)N=3)SC=2C=CC=1)=O.[CH:35]1([NH:38][C:39]([C:41]2[C:49]3[CH:48]=[C:47]([C:50]4[C:55]([CH3:56])=[CH:54][N:53]=[C:52]([Cl:57])[N:51]=4)[S:46][C:45]=3[CH:44]=[CH:43][CH:42]=2)=[O:40])[CH2:37][CH2:36]1.[CH3:58][N:59]1[CH2:64][CH2:63][N:62]([CH2:65][CH2:66][NH2:67])[CH2:61][CH2:60]1>>[ClH:57].[ClH:1].[ClH:57].[CH:35]1([NH:38][C:39]([C:41]2[C:49]3[CH:48]=[C:47]([C:50]4[C:55]([CH3:56])=[CH:54][N:53]=[C:52]([NH:67][CH2:66][CH2:65][N:62]5[CH2:63][CH2:64][N:59]([CH3:58])[CH2:60][CH2:61]5)[N:51]=4)[S:46][C:45]=3[CH:44]=[CH:43][CH:42]=2)=[O:40])[CH2:37][CH2:36]1

Participants

4

Reactant 3

HCID 702844-Methylpiperazine-1-ethylamineHCID 688589832-{5-Methyl-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid methylamide tri-hydrochlorideHCID 866253772-(2-Chloro-5-methylpyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide

Product 1

HCID 688598302-{5-Methyl-2-[2-(4-methylpiperazin-1-yl)-ethylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride

Procedure

Using the method of 2-{5-methyl-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid methylamide tri-hydrochloride, the title compound is synthesized from [2-(2-chloro-5-methylpyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide and 2-(4-methylpiperazin-1-yl)-ethylamine and isolated as a yellow solid. ES+(m/z) 451 [M(free base)+H].

Workup

  1. customisolated as a yellow solid

Sources & evidence

ORD record
ord-419311423f9f4f0bad17bc6175787598
Source dataset
uspto-grants-2009_06
Patent number
US07547691B2

Reaction notes

Loading…