Ethyl cyanoacetate → HCID 68871582, compound

Participants

Reaction Conditions

Reaction Steps

The product from Step 3 (2.9 g, 8.3 mmol) and ethyl cyanoacetate (6 mL) were combined and heated to 195° C. in a sealed tube. The reaction mixture was cooled and the crude material was purified by chromatography (0-10% methanol in EtOAc) to give the title compound (2.6 g, 78%). MS (ES+) m/e 400 [M+H]+.

Provenance & Evidence