HCID 68872196, compound → HCID 68875465, compound

HRID 1986361Notes

Reaction equation

HRID 1986361 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([NH:18][C:19]3[C:24]([N+:25]([O-])=O)=[CH:23][N:22]=[C:21]([O:28][C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([NH:35][C:36](=[O:38])[CH3:37])[CH:30]=4)[CH:20]=3)=[CH:13][CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([NH:18][C:19]3[C:24]([NH2:25])=[CH:23][N:22]=[C:21]([O:28][C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([NH:35][C:36](=[O:38])[CH3:37])[CH:30]=4)[CH:20]=3)=[CH:13][CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 68872196HCID 68872196, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68875465HCID 68875465, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The product from Step 2 (2.7 g, 5.2 mmol) was dissolved in MeOH (20 mL), Pd/C (5% on C, 100 mg) was added the mixture was hydrogenated with a balloon of hydrogen for 2 days, then filtered through celite. The filtrate was concentrated to give the title compound which was taken on without purification. MS (ES+) m/e 491 [M+H]+.

Workup

  1. filtrationfiltered through celite
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-94aa4930fba843a1a622c1d985cba9e5
Source dataset
uspto-grants-2009_06
Patent number
US07547779B2

Reaction notes

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