HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl cyanoacetate → (6-Bromo-1-phenyl-1H-imidazo[4,5-c]pyridin-2-yl)acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | 6-bromo-N4-phenylpyridine-3,4-diamine | HCID 86045127 | — |
| Product | (6-Bromo-1-phenyl-1H-imidazo[4,5-c]pyridin-2-yl)acetonitrile | HCID 86045130 | 35% |
Reaction Steps
The product from Step 4 (2.1 g, 7.95 mmol) and ethyl cyanoacetate (3.6 g, 31 mmol) were heated together at 195° C. in a sealed tube for 54 minutes. After cooling to room temperature, the product crystallized and the crystals were collected and washed with ethanol to give the title compound (0.87 g, 35%). MS (ES+) m/e 313/315 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547779B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-65edebe5e52b49d0b25d5a482dded18f |
| Source note | uspto-grants-2009_06 |