Diisopropylethylamine → 3-{[2-(4-amino-furazan-3-yl)-1-phenyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}-N-[2-(4-morpholinyl)ethyl]benzamide

Participants

Reaction Steps

The product from Step 9 (0.020 g, 0.048 mmol) in dichloromethane (2 mL) and N,N-diisopropylethylamine (0.02 mL, 0.11 mmol) was treated with N-(2-aminoethyl)morpholine and the PyBoP reagent (2 equiv) and stirred at rt for 2 h. The reaction mixture was concentrated and the residue was purified by reverse phase HPLC to give the compound (0.008 g, 31%). MS (ES+) m/e 527 [M+H]+.

Provenance & Evidence