HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-1,4-cyclohexadiene → 1-(3-Hydroxyphenyl)-4-(4-morpholinyl)-1-butanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-1,4-cyclohexadiene | HCID 78006 | — |
| Reactant | 4-(4-Morpholinyl)-1-{3-[(phenylmethyl)oxy]phenyl}-1-butanone | HCID 68874142 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(3-Hydroxyphenyl)-4-(4-morpholinyl)-1-butanone | HCID 68875422 | 99% |
Reaction Steps
To a solution of the product of Step 3 (352 mg, 1.04 mmol) in EtOH (15 mL), was added 10% palladium on carbon (50 mg), followed with 1-methyl-1,4-cyclohexadiene (1.5 mL). This suspension was then heated to reflux for 45 min. The reaction mixture was filtered and concentrate to afford the title compound as a white solid (255 mg, 99%). MS (ES+) m/e 250 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547779B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-cffcbc2994174a69bf516a05463aa714 |
| Source note | uspto-grants-2009_06 |