1-Methyl-1,4-cyclohexadiene → 3-[3-(4-Methyl-1-piperazinyl)-3-oxopropyl]phenol

Participants

Reaction Steps

To a solution the product of Example 17, Step 1 (300 mg, 1.22 mmol) in EtOH (15 mL), was added 10% palladium on carbon (50 mg), followed with 1-methyl-1,4-cyclohexadiene (1.5 mL). This suspension was then heated to reflux for 45 min. The reaction mixture was filtered and concentrated to afford the title compound, as a white solid (291 mg, 96%). MS (ES+) m/e 249 [M+H]+.

Provenance & Evidence