Boron tribromide → HCID 28303003, compound

Participants

Reaction Conditions

Reaction Steps

A solution of boron tribromide (1M in CH2Cl2, 20 mL, 20 mmol) was added to a −78° C. solution of the product of Step 1 in CH2Cl2 (50 mL) and the resulting mixture was allowed to warm to 0° C. After 2 h at 0° C. the mixture was re-cooled to −78° C. and quenched with sat. aq. NaHCO3 solution and allowed to warm to rt. The mixture was extracted with EtOAc, and the organic layers was washed with H2O and brine, dried (MgSO4), filtered and the filtrate was concentrated to give the title compound as a crude oil (1.9 g, 66%) which was used directly in the next step. MS (ES+) m/e 287 [M+H]+.

Provenance & Evidence