Water → HCID 68875466, compound

HRID 1986406Notes

Reaction equation

HRID 1986406 reaction equation
[O:1]=[C:2]1[NH:7][CH:6]=[C:5]([C:8](Cl)=[O:9])[CH:4]=[CH:3]1.[NH2:11][C:12]1[CH:13]=[C:14]([O:18][C:19]2[N:24]=[CH:23][C:22]3[N:25]=[C:26]([C:30]4[C:31]([NH2:35])=[N:32][O:33][N:34]=4)[N:27]([CH2:28][CH3:29])[C:21]=3[CH:20]=2)[CH:15]=[CH:16][CH:17]=1.O>N1C=CC=CC=1>[NH2:35][C:31]1[C:30]([C:26]2[N:27]([CH2:28][CH3:29])[C:21]3[CH:20]=[C:19]([O:18][C:14]4[CH:13]=[C:12]([NH:11][C:8]([C:5]5[CH:4]=[CH:3][C:2](=[O:1])[NH:7][CH:6]=5)=[O:9])[CH:17]=[CH:16][CH:15]=4)[N:24]=[CH:23][C:22]=3[N:25]=2)=[N:34][O:33][N:32]=1

Participants

5

Reactant 3

HCID 962WaterHCID 11404963HCID 11404963, compoundHCID 12018575HCID 12018575, compound

Product 1

HCID 68875466HCID 68875466, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The product of Step 1 (93 mg, 0.6 mmol) was added to a solution of the product of Example 3 (200 mg, 0.6 mmol) in pyridine (1 mL) and the resulting mixture was allowed to stir at rt for 30 min. The solution was poured into H2O and the precipitate which formed as filtered, washed with H2O and Et2O and dried to give the title compound as a tan solid (150 mg, 55%). MS (ES+) m/e 459 [M+H]+.

Workup

  1. customthe precipitate which formed
  2. filtrationas filtered
  3. washwashed with H2O and Et2O
  4. customdried

Sources & evidence

ORD record
ord-e1e8fa2b4b38458ea761f5187401689a
Source dataset
uspto-grants-2009_06
Patent number
US07547779B2

Reaction notes

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