Hydrazine hydrate (1:1) → HCID 68832589, compound

Participants

Reaction Steps

To a solution of 2-[(6-chloro-2-isobutyl-4-phenylquinolin-3-yl)methyl]-1H-isoindole-1,3(2H)-dione (0.54 g, 1.18 mmol) in ethanol (50 ml), being-heated under reflux, was added hydrazine monohydrate (3 ml, 62 mmol), and the mixture was heated under reflux for 2 hrs. The reaction mixture was partitioned between ethyl acetate (100 ml) and saturated aqueous sodium hydrogen carbonate (50 ml)-water (100 ml). The organic layer was washed with saturated aqueous sodium hydrogen carbonate (50 ml) and then saturated brine (20 ml), and dried over anhydrous magnesium sulfate. The solvent was evaporated and the residue was purified by silica gel column chromatography, and crystallized from n-hexane to give the title compound (0.28 g, yield 73%) as pale-yellow crystals.

Provenance & Evidence