Hydrochloric Acid → HCID 68830162, compound

Participants

Reaction Steps

To a solution of 3-{[(tert-butoxycarbonyl)amino]methyl}-2-isobutyl-4-phenylquinoline-6-carboxylic acid (0.10 g, 0.23 mmol) in tetrahydrofuran (4 ml) was added 4N solution of hydrogen chloride in ethyl acetate (4 ml), and the mixture was stirred at room temperature for 4 hrs. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from diisopropyl ether-ethyl acetate to give the title compound (0.078 g, yield 82%) as colorless crystals.

Provenance & Evidence