Ammonia → HCID 68829511, compound

Participants

Reaction Steps

To a mixture of 2-isobutyl-6-methoxy-4-phenylquinoline-3-carbonitrile (1.00 g, 3.16 mmol), 25% aqueous ammonia (4 ml), tetrahydrofuran (30 ml) and methanol (50 ml) was added Raney-nickel (1 ml) and the mixture was stirred under a hydrogen atmosphere at 0.5 MPa, room temperature for 6 hrs. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography and recrystallized from n-hexane-ethyl acetate to give the title compound (0.44 g, yield 44%) as colorless crystals.

Provenance & Evidence