HCID 86605630, compound → HCID 86605644, compound

Participants

Reaction Steps

To a solution of tert-butyl {[6-[(1E)-3-amino-3-oxoprop-1-en-1-yl]-2-isobutyl-4-(4-methylphenyl)-quinolin-3-yl]methyl}carbamate (250 mg, 0.53 mmol) in methanol (5 ml) and tetrahydrofuran (5 ml) was added 5% palladium-carbon (0.10 g), and the mixture was stirred under a hydrogen atmosphere at room temperature for 12 hrs. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was crystallized from diisopropyl ether to give tert-butyl {[6-(3-amino-3-oxopropyl)-2-isobutyl-4-(4-methylphenyl)quinolin-3-yl]methyl}carbamate (204 mg, yield 81%) as white crystals.

Provenance & Evidence