HCID 86605659, compound → HCID 68829553, compound

Participants

Reaction Steps

A solution of tert-butyl {[6-(4-amino-4-oxobutoxy)-2-isobutyl-4-(4-methylphenyl)quinolin-3-yl]methyl}carbamate (0.5 g, 0.99 mmol) in trifluoroacetic acid (10 ml) was stirred at 0° C. for 3 hrs. The reaction mixture was concentrated under reduced pressure and the residue was dissolved in ethyl acetate. The obtained-solution was washed twice with saturated aqueous sodium hydrogen carbonate, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was crystallized from diethyl ether to give the title compound (0.25 g, yield 63%) as crystals.

Provenance & Evidence