反应详情

温度

0 °C

24 mg (50 μmol) of product 5, and then 2 ml of a cold trifluoroacetic acid/tetrahydrofuran/water mixture (1.6/1.6/1.0 v/v/v) are successively introduced, at 0° C., into a round-bottomed flask equipped with a magnetic stirrer. This mixture is maintained at 0° C. until the starting material has disappeared on TLC (1 hour) (90/10 v/v dichloromethane/methanol). The solvent is evaporated off under reduced pressure and 2 ml of methanol are added to the residue, which is reevaporated under reduced pressure. This last step is repeated a second time and the residue is dissolved in 5 ml of water in a minimum volume of methanol (0.5 ml). The solution is freeze-dried, giving the expected product Example 1 quantitatively in the form of a foam.

1. customequipped with a magnetic stirrer
2. customThe solvent is evaporated off under reduced pressure and 2 ml of methanol
3. additionare added to the residue, which
4. customis reevaporated under reduced pressure
5. dissolutionthe residue is dissolved in 5 ml of water in a minimum volume of methanol (0.5 ml)
6. customThe solution is freeze-dried