Hydrochloric Acid → HCID 57722285, compound

Participants

Reaction Steps

40 mg of 44 (70 μmol) are mixed with 0.38 ml of THF and 0.75 ml of 1N hydrochloric acid, with stirring and under argon. Stirring is continued for 5 hours at room temperature. The solution is then cooled to 0° C. and neutralized to pH 7.0 with 1N sodium hydroxide. The mixture is extracted twice with 2 ml of EtOAc. The organic phases are combined, dried over magnesium sulfate and filtered and then evaporated to dryness. 25 mg of expected product Example 16 are obtained (yield=67%).

Provenance & Evidence