Hydrochloric Acid → HCID 57722289, compound

Participants

Reaction Steps

81 mg of 49 (148 μmol) are mixed with 0.75 ml of THF and 1.5 ml of 1N hydrochloric acid (750 μmol), with stirring and under argon. Stirring is continued for 5 hours at room temperature. The solution is then cooled to 0° C. and neutralized to pH 7.0 with 1N sodium hydroxide. The mixture is extracted twice with 2 ml of EtOAc. The organic phases are combined, dried over magnesium sulfate and filtered, and then evaporated to dryness. 49 mg of expected product Example 18 are obtained (yield=66%).

Provenance & Evidence