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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1986553Generated: October 26, 2026

Piperazine → Norquetiapine

https://huagongshe.com/reaction/1986553

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperazineHCID 4837—
ReactantDibenzothiazepinoneHCID 374829—
ProductNorquetiapineHCID 1136991810.5%

Reaction Steps

10H-Dibenzo[b,f][1,4]thiazepin-11-one (23 mg, 0.1 mmol) and piperazine (43 mg, 0.5 mmol) were reacted according to GP4 to give 3.1 mg of the title compound (160FE17A). MS (ESI) 296 (MH+). Purity for MH+ (UV/MS) 97/90.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07550454B2
Source datasetuspto-grants-2009_06
ORD IDord-9e5e45ae900e4d16a247bbba34df9172
Source noteuspto-grants-2009_06