HCID 57485434, compound → HCID 136029241, compound

HRID 1986578Notes

Reaction equation

HRID 1986578 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8](SC)=[N:7][C:6]=2[CH:18]=1.C(OC([NH:26][CH:27]1[CH2:32][CH2:31][N:30](N)[CH2:29][CH2:28]1)=O)(C)(C)C>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8]([N:30]3[CH2:31][CH2:32][CH:27]([NH2:26])[CH2:28][CH2:29]3)=[N:7][C:6]=2[CH:18]=1

Participants

3

Reactant 2

HCID 57485434HCID 57485434, compoundHCID 136056013HCID 136056013, compound

Product 1

HCID 136029241HCID 136029241, compoundYield 18.1%

Procedure

8-Chloro-11-methylsulfanyl-5H-dibenzo[b,e][1,4]diazepine (166JO50) (50 mg, 0.11 mmol) and 4-(tert-butoxycarbonylamino)-aminopiperidine (39 mg, 0.2 mmol) were reacted according to GP8 to give 6.5 mg of the title compound (166JO55). MS (ESI) 327 (MH+). Purity for MH+ (UV/MS) 100/99.

Sources & evidence

ORD record
ord-6bc19865fbca4583a8dcd4df6533612e
Source dataset
uspto-grants-2009_06
Patent number
US07550454B2

Reaction notes

Loading…