tert-butyl N-(pyrrolidin-3-yl)carbamate → HCID 136029242, compound

HRID 1986579Notes

Reaction equation

HRID 1986579 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8](SC)=[N:7][C:6]=2[CH:18]=1.C(OC([NH:26][CH:27]1[CH2:31][CH2:30][NH:29][CH2:28]1)=O)(C)(C)C>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8]([N:29]3[CH2:30][CH2:31][CH:27]([NH2:26])[CH2:28]3)=[N:7][C:6]=2[CH:18]=1

Participants

3

Reactant 2

HCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamateHCID 136056013HCID 136056013, compound

Product 1

HCID 136029242HCID 136029242, compoundYield 11.8%

Procedure

8-Chloro-11-methylsulfanyl-5H-dibenzo[b,e][1,4]diazepine (166JO50) (100 mg, 0.22 mmol) and 3-(tert-butoxycarbonylamino)pyrrolidine (73 mg, 0.4 mmol) were reacted according to GP8 to give 8.1 mg of the title compound (166JO64). MS (ESI) 313 (MH+). Purity for MH+ (UV/MS) 100/94.

Sources & evidence

ORD record
ord-0803b469975849b69ff69cdf6fe95c8f
Source dataset
uspto-grants-2009_06
Patent number
US07550454B2

Reaction notes

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