HCID 68630790, compound → HCID 135620682, compound

HRID 1986581Notes

Reaction equation

HRID 1986581 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8](SC)=[N:7][C:6]=2[CH:18]=1.C(OC(N[N:27]1[CH2:32][CH:31]2[CH2:33][CH:28]1[CH2:29][NH:30]2)=O)(C)(C)C>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8]([N:27]3[CH2:32][CH:31]4[CH2:33][CH:28]3[CH2:29][NH:30]4)=[N:7][C:6]=2[CH:18]=1

Participants

3

Reactant 2

HCID 68630790HCID 68630790, compoundHCID 136056013HCID 136056013, compound

Product 1

HCID 135620682HCID 135620682, compoundYield 42%

Procedure

8-Chloro-11-methylsulfanyl-5H-dibenzo[b,e][1,4]diazepine (166JO50) (50 mg, 0.11 mmol) and N-(tert-butoxycarbonylamino)-2,5-diazabicyclo[2.2.1]heptane (34 mg, 0.2 mmol) were reacted according to GP8 to give 15 mg of the title compound (166JO39-2). MS (ESI) 324 (MH+). Purity for MH+ (UV/MS) 93/100.

Sources & evidence

ORD record
ord-adb76b838d8a413e8129182b76087fd8
Source dataset
uspto-grants-2009_06
Patent number
US07550454B2

Reaction notes

Loading…