反应详情

1.5 g of intermediate A1 are dissolved in a mixture of 15 ml methanol and 15 ml dichloromethane. 1 g of solid KOH is added. The mixture is heated up to reflux for 7 hours. At room temperature 30 ml water are added. The organic layer is separated. The aqueous layer is extracted with 20 ml dichloromethane. The unified organic layers are washed with 2×20 ml water. The solvent is removed completely. The residue is purified by LC.

1. temperatureThe mixture is heated up
2. temperatureto reflux for 7 hours
3. customThe organic layer is separated
4. extractionThe aqueous layer is extracted with 20 ml dichloromethane
5. washThe unified organic layers are washed with 2×20 ml water
6. customThe solvent is removed completely
7. customThe residue is purified by LC