反应详情

温度

40 °C

To a solution prepared of 138.2 g 6-methoxy-2-(4-methyl-2-propyl-imidazol-1-yl)-3-nitro-pyridine and 900 ml ethyl alcohol 4 g palladium-charcoal were added. The reaction mixture was heated to 40° C. and then hydrogenated under pressure (10 to 15 bar). At room temperature the catalyst was filtrated off and the filtrate was evaporated. To the solid residue 150 ml methyl tert.-butyl ether (MTBE) were added. After stirring for 30 minutes the product was collected by filtration, washed with 50 ml MTBE for 2 times and dried in a dry box with vacuum (40° C.).

1. additionwere added
2. filtrationAt room temperature the catalyst was filtrated off
3. customthe filtrate was evaporated
4. additionTo the solid residue 150 ml methyl tert.-butyl ether (MTBE) were added
5. filtrationwas collected by filtration
6. washwashed with 50 ml MTBE for 2 times
7. customdried in a dry box with vacuum (40° C.)