反应详情

To a suspension of 7-nitro-benzo[b]thiophene-2-carboxylic acid methyl ester (1.0 g) in THF/MeOH (40 mL/40 mL) was added 8.4 mL (2.0 eq) of 1N NaOH. The reaction was stirred at room temperature for 2 h. The solvent was removed in vacuo. The residue was diluted with H2O/EtOAc, acidified with 3N HCl and extracted with EtOAc. The organics were dried over MgSO4, filtered and concentrated to give 7-nitro-benzo[b]thiophene-2-carboxylic acid as a light yellow solid (928 mg, 98% yield).

1. customThe solvent was removed in vacuo
2. additionThe residue was diluted with H2O/EtOAc
3. extractionextracted with EtOAc
4. dry with materialThe organics were dried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated