HCID 10055409, compound → HCID 10347968, compound

Participants

Reaction Conditions

Reaction Steps

To N-[2-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-benzo[b]thiophen-7-yl]-6-(4-methoxy-benzylamino)-nicotinamide (Example 1) (20 mg) in a sealed tube was added 90 μL of trifluoroacetic acid. The clear solution was purged with Ar and then heated to 75° C. in a sealed tube 12 h. The reaction was cooled to room temperature and diluted with toluene to remove excess trifluoroacetic acid in vacuo. The resulting trifluoroacetic acid salt of the desired product was dissolved in EtOAc and washed with saturated NaHCO3 solution and brine. The organics were dried over MgSO4, filtered and concentrated to give a foam which was further purified by flash chromatography on silica gel (7%-10% MeOH/CH2Cl2) to provide the title compound as a white solid (14 mg, 85% yield), m.p. 234-235° C.

Provenance & Evidence