Cyclopropylamine → HCID 9986150, compound

Participants

Reaction Conditions

Reaction Steps

To N-(2-{5-tert-butyl-3-[(6-chloro-pyridine-3-carbonyl)-methanesulfonyl-amino]-2-methoxy-phenylcarbamoyl}-benzo[b]thiophen-7-yl)-6-chloro-nicotinamide (see Example 1) (33 mg) in a sealed tube was added 200 μL of cyclopropylamine. The reaction was purged with Ar and heated to 100° C. in the sealed tube 12 h. The reaction mixture was cooled to room temperature and diluted with EtOAc, washed by NH4Cl solution, water, and brine. The organics were dried over MgSO4, filtered, concentrated down to give a residue which was purified by flash chromatography on silica gel (CH2Cl2-2% MeOH/CH2Cl2) to provide the title compound (21 mg, 71%), m.p. >264° C. dec.

Provenance & Evidence