Methyl chloroformate → HCID 58817546, compound

HRID 1986947Notes

Reaction equation

HRID 1986947 reaction equation
[CH3:1][O:2][C:3]([C:5]1[S:9][C:8]2[CH:10]=[C:11]([C:14]([F:17])([F:16])[F:15])[CH:12]=[CH:13][C:7]=2[C:6]=1[CH:18]1[CH2:23][CH2:22][N:21](CC2C=CC=CC=2)[CH2:20][CH2:19]1)=[O:4].Cl[C:32]([O:34][CH3:35])=[O:33]>C(Cl)Cl>[CH3:35][O:34][C:32]([N:21]1[CH2:22][CH2:23][CH:18]([C:6]2[C:7]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:15])[F:16])=[CH:10][C:8]=3[S:9][C:5]=2[C:3]([O:2][CH3:1])=[O:4])[CH2:19][CH2:20]1)=[O:33]

Participants

4

Reactant 2

HCID 6586Methyl chloroformateHCID 58817541HCID 58817541, compound

Product 1

HCID 58817546HCID 58817546, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-(1-benzyl-piperidin-4-yl)-6-trifluoromethyl-benzo[b]thiophene-2-carboxylic acid methyl ester (5.9 g, 13.6 mmol) in DCM (50 mL) was added methyl chloroformate (1.26 mL, 16.3 mmol) drop-wise. The resulting solution was stirred overnight when the volatiles were removed in vacuo. The residue was washed with heptane to yield 4.2 g (77%) of the desired product as a white solid.

Workup

  1. customwere removed in vacuo
  2. washThe residue was washed with heptane

Sources & evidence

ORD record
ord-88ddb79ad91449d58adc7beaa21745f3
Source dataset
uspto-grants-2009_06
Patent number
US07550469B2

Reaction notes

Loading…