HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Chloro-7,7-dimethyl-7,8-dihydroquinolin-5(6H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 7,7-dimethyl-7,8-dihydroquinoline-2,5(1H,6H)-dione | HCID 13516379 | — |
| Product | 2-Chloro-7,7-dimethyl-7,8-dihydroquinolin-5(6H)-one | HCID 14812545 | 60% |
Reaction Steps
In analogy to (Shanazarov, A. K.; Kuzovkin, V. A.; Chistjakov, V. V.; Granik, V. G. Khim. Geterotsikl. Soedin. 1991, (1) 86-92.) 7,7-dimethyl-7,8-dihydro-1H,6H-quinoline-2,5-dione was treated with phosphoryl chloride (POCl3) to give the title compound as a gray solid in 60% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07550482B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-12a0870e821748d092d04e8053782be7 |
| Source note | uspto-grants-2009_06 |