HCID 68851910, compound → HCID 86621022, compound

HRID 1987006Notes

Reaction equation

HRID 1987006 reaction equation
[ClH:1].Cl.[CH3:3][N:4]1[CH2:10][CH2:9][CH2:8][N:7]([CH2:11][CH:12]([C:24]2(O)[CH2:27][CH2:26][CH2:25]2)[C:13]2[CH:18]=[CH:17][C:16]([O:19][C:20]([F:23])([F:22])[F:21])=[CH:15][CH:14]=2)[CH2:6][CH2:5]1.CN1CCCN(C(=O)C(C2(O)CCC2)C2C=CC([O:45]C(F)(F)F)=CC=2)CC1>>[ClH:1].[ClH:1].[CH3:3][N:4]1[CH2:10][CH2:9][CH2:8][N:7]([CH2:11][CH:12]([CH:24]2[CH2:25][CH2:26][CH:27]2[OH:45])[C:13]2[CH:14]=[CH:15][C:16]([O:19][C:20]([F:23])([F:22])[F:21])=[CH:17][CH:18]=2)[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 68851910HCID 68851910, compoundHCID 68854650HCID 68854650, compound

Product 1

HCID 86621022HCID 86621022, compound

Procedure

In an analogous manner to Example 1, step 2 1-{2-(4-methyl-1,4-diazepan-1-yl)-1-[4-(trifluoromethoxy)phenyl]ethyl)cyclobutanol dihydrochloride was prepared from 1-{2-(4-methyl-1,4-diazepan-1-yl)-1-[4-(trifluoromethoxy)phenyl]-2-oxo-ethyl)cyclobutanol.

Sources & evidence

ORD record
ord-95b40a5a2d4e46c08065f0e8463800ef
Source dataset
uspto-grants-2009_06
Patent number
US07550456B2

Reaction notes

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