4-(N-Boc-amino)piperidine → HCID 86760656, compound

HRID 1987008Notes

Reaction equation

HRID 1987008 reaction equation
[OH:1][C:2]1([CH:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:13]=2)[C:9](O)=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[CH3:25][C:26]([O:29][C:30]([NH:32][CH:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1)=[O:31])([CH3:28])[CH3:27]>>[OH:1][C:2]1([CH:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:13]=2)[C:9]([N:36]2[CH2:35][CH2:34][CH:33]([NH:32][C:30](=[O:31])[O:29][C:26]([CH3:25])([CH3:27])[CH3:28])[CH2:38][CH2:37]2)=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 7238334-(N-Boc-amino)piperidineHCID 68893247HCID 68893247, compound

Product 1

HCID 86760656HCID 86760656, compound

Procedure

In an analogous manner to Example 1′ step 1, tert-butyl (1-{(1-hydroxycyclohexyl)[3-(phenoxy)phenyl]acetyl}piperidin-4-yl)carbamate was prepared from (1-hydroxycyclohexyl)[3-phenoxyphenyl]acetic acid (Reference Example 1-ccc) and 4-N-BOC-aminopiperidine. MS (ESI) m/z 509 ([M+H]+).

Sources & evidence

ORD record
ord-b0d1114e1481493ab6a0c9d0318d2e86
Source dataset
uspto-grants-2009_06
Patent number
US07550456B2

Reaction notes

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