HCID 68854741, compound → 1-(1-[3-fluoro-4-[(4-methylbenzyl)oxy]phenyl}-2-piperazin-1-ylethyl)cyclohexanol Dihydrochloride

HRID 1987014Notes

Reaction equation

HRID 1987014 reaction equation
[ClH:1].Cl.[F:3][C:4]1[CH:5]=[C:6]([CH:22]([C:31]2([OH:37])[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]2)[CH2:23][N:24]2[CH2:29][CH2:28][N:27](C)[CH2:26][CH2:25]2)[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18](F)(F)F)=[CH:14][CH:13]=1.FC1C=C(C(C2(O)CCCCC2)C(N2CCN(C(OC(C)(C)C)=O)CC2)=O)C=CC=1OCC1C=CC(C)=CC=1>>[ClH:1].[ClH:1].[F:3][C:4]1[CH:5]=[C:6]([CH:22]([C:31]2([OH:37])[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]2)[CH2:23][N:24]2[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]2)[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][C:12]1[CH:13]=[CH:14][C:15]([CH3:18])=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 68854741HCID 68854741, compoundHCID 865990571-[1-(3-Fluoro-4-{[4-(trifluoromethyl)benzyl]oxy}phenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclohexanol dihydrochloride

Product 1

HCID 688553321-(1-[3-fluoro-4-[(4-methylbenzyl)oxy]phenyl}-2-piperazin-1-ylethyl)cyclohexanol Dihydrochloride

Procedure

In an analogous manner to Example 1, step 2 1-[1-(3-fluoro-4-{[4-(trifluoromethyl)benzyl]oxy}phenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclohexanol dihydrochloride was prepared from tert-butyl 4-[(3-fluoro-4-{[4-(methyl)benzyl]oxy}phenyl)(1-hydroxycyclohexyl)acetyl]piperazine-1-carboxylate. MS (ESI) m/z 427; HRMS: calcd for C26H35FN2O2+H+, 427.27553; found (ESI, [M+H]+), 427.2776.

Sources & evidence

ORD record
ord-705990c88fbb4e5589297845685fa17c
Source dataset
uspto-grants-2009_06
Patent number
US07550456B2

Reaction notes

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