Potassium Carbonate → HCID 10253075, compound

Participants

Reaction Steps

N-(2-Chlorophenyl)-3-[4,6-dibromo-2-(2-chlorophenyl)-3-pyridinyl]propanamide (942 mg, 1.78 mmol) was divided into six portions and each dissolved in DMF (3 ml), and treated with potassium carbonate (50 mg, 0.362 mmol) and copper(I) iodide (15 mg, 0.079 mmol), and heated in a Smith Creator microwave at 180° for 15 min. All reactions were then combined and evaporated in vacuo. The residue was treated with water (15 ml) and extracted with dichloromethane (2×20 ml). The extracts were passed through a hydrophobic frit and evaporated in vacuo. The residue was purified by column chromatography over silica (20 g) eluting with a cyclohexane-ethyl acetate gradient (100:0-0:100). (70:30) gave the product as a white foam (406 mg, 51%).

Provenance & Evidence