HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → HCID 10321326, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 10253075 | HCID 10253075 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10321326 | HCID 10321326 | — |
Reaction Steps
7-Bromo-1,5-bis(2-chlorophenyl)-3,4-dihydro[1,6]naphthyridin-2(1H)-one (30 mg, 0.067 mmol) in carbon tetrachloride (5 ml) was treated with NBS (15 mg) and AlBN (1.1 mg) and heated under reflux for 1.5 h. DBU (10 μl) was added, the mixture cooled, and dichloromethane (5 ml) added, followed by 8% sodium bicarbonate (10 ml). The mixture was passed through a hydrophobic frit and evaporated in vacuo to give the product as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07550480B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-1fa692eb4ee343f3a2ae2e262cc03c70 |
| Source note | uspto-grants-2009_06 |