Potassium Carbonate → HCID 57722976, compound

Participants

Reaction Steps

N-(2-chlorophenyl)-3-(2,6-dibromo-4-methoxyphenyl)propanamide (1.40 g, 3.128 mmol), copper(I) iodide (0.895 g, 4.694 mmol), and potassium carbonate (0.865 g, 6.259 mmol) in DMF (15 ml), were heated under reflux for 30 min., cooled and evaporated in vacuo. The residue was treated with 2M hydrochloric acid (80 ml) and extracted with dichloromethane (2×50 ml). The extracts were passed through a hydrophobic frit, evaporated in vacuo and the residue purified by flash chromatography over silica (50 g) eluting with cyclohexane-ethyl acetate gradient (100:0-50:50) to give the product as a white solid (0.714 g, 62%)

Provenance & Evidence