Boron tribromide → HCID 57722970, compound

Participants

Reaction Steps

1,5-bis(2-chlorophenyl)-7-methoxy-2(1H)-quinolinone (0.863 g, 2.178 mmol) was dissolved in dichloromethane (40 ml) and 1M boron tribromide in dichloromethane (12 ml) added slowly under nitrogen. The solution was stirred at 21° for 4 h, then quenched carefully with methanol (3 ml) and ice (25 g). The mixture was passed through a hydrophobic frit, and the aqueous phase further extracted with dichloromethane (20 ml), and passed through a hydrophobic frit. The dichloromethane extracts were combined and evaporated in vacuo to afford the title compound as a dark solid (0.784 g, 94%).

Provenance & Evidence