Cesium carbonate → HCID 10321773, compound

Participants

Reaction Steps

1,5-bis(2-chlorophenyl)-2-oxo-1,2-dihydro-7-quinolinyl trifluoromethanesulfonate (50 mg, 0.097 mmol), serinol (44 mg, 0.483 mmol), racemic BINAP (74 mg, 0.19 mmol), palladium(II) acetate (17 mg, 0.076 mmol), and cesium carbonate (0.14 g, 0.43 mmol) in 1,4-dioxan (2 ml) were heated in a Smith creator microwave at 130° for 15 min. Water (3 ml) and chloroform (4 ml) were added to the reaction mixture, which was then passed through a hydrophobic frit, and blown down under a stream of nitrogen. The residue was purified by mass directed autoprep to afford the title compound as a gum (7 mg, 16%).

Provenance & Evidence