Potassium Carbonate → HCID 86607812, compound

Participants

Reaction Steps

3-[6-Chloro-4-(2-chlorophenyl)-3-pyridinyl]-N-(2-chlorophenyl)propanamide (1.51 g, 3.43 mmol) was dissolved in DMF (40 ml), potassium carbonate (0.95 g, 6.87 mmol) and copper(I) iodide (1.3 g, 6.83 mmol) added and the mixture heated at reflux for 1 h. Most of the DMF was removed in vacuo, the residue was treated with water (10 ml) and brine (10 ml), and extracted with dichloromethane (2×15 ml) and ethyl acetate (15 ml). The extracts were passed through a hydrophobic frit and evaporated in vacuo to give the title compound as an off-white solid (1.6 g)

Provenance & Evidence