N-methyl-2-pyrrolidone → HCID 68987357, compound

Participants

Reaction Steps

7-chloro-1,5-bis(2-chlorophenyl)[1,8]naphthyridin-2(1 h-one (73 mg, 0.182 mmol) and serinol (75 mg, 0.823 mmol) were dissolved in N-methylpyrrolidinone (2 ml) and heated in a Smith Creator microwave at 220° for 30 min. The mixture was evaporated in vacuo using a vacuum centrifuge, and the residue purified by mass directed autoprep HPLC (per general procedure B) to afford the title compound as a white solid (33 mg, 36%) NMR (400 MHz, CDCl3) δ 7.65-7.55 (2H,m), 7.52-7.42 (4H,m), 7.40-7.29 (3H,m), 6.40 (1H,s), 6.35 (1H,dd), 3.55-3.42 (5H,m)

Provenance & Evidence