Ammonia → HCID 57722721, compound

HRID 1987055Notes

Reaction equation

HRID 1987055 reaction equation
[NH3:1].CO.C([O:6][C:7](=O)[C:8]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=1)([F:10])[F:9])C>>[Cl:17][C:13]1[CH:12]=[C:11]([C:8]([F:10])([F:9])[C:7]([NH2:1])=[O:6])[CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 887MethanolHCID 15728458Ethyl (3-chlorophenyl)(difluoro)acetate

Product 1

HCID 57722721HCID 57722721, compoundYield 95%

Procedure

To a solution of NH3 in MeOH (2 M, 50 mL, 100 mmol) was added (3-chlorophenyl)difluoroacetic acid ethyl ester (4.78 g, 20.4 mmol), as prepared in the preceding step. The homogeneous yellow solution was allowed to sit at room temperature for 13 h, and was then concentrated to provide 3.99 g (95%) of the title compound as a yellow powder. 1H NMR (300 MHz, DMSO-d6) δ 8.41 (br, 1H), 8.09 (br, 1H), 7.68-7.60 (m, 2H), 7.59-7.52 (m, 2H).

Workup

  1. customas prepared in the preceding step
  2. concentrationwas then concentrated

Sources & evidence

ORD record
ord-a69a4461eee04d88b5bc9e90f4a4a21c
Source dataset
uspto-grants-2009_06
Patent number
US07550474B2

Reaction notes

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