Hydrochloric Acid → HCID 178425034, compound

Participants

Reaction Steps

Prepared from N-[2-(Amidinoaminooxy)ethyl]-2-{3-[(2,2-difluoro-2-(6-methylpyridyl)ethyl)amino]-6-cyano-2-fluorophenyl}acetamide, as described in the previous step, using the protocol given in Example 1m, except the product collected by filtration was not recrystallized. 1H NMR (CD3OD) δ 8.38 (m, 1H), 7.91 (m, 2H), 7.33 (d, J=8.73 Hz, 1H), 6.92 (t, J=8.65 Hz, 1H), 4.20 (t, J=13.40 Hz, 2H), 3.96 (t, J=5.37 Hz, 2H), 3.78 (d, J=1.91 Hz, 2H), 3.52 (t, J=5.33 Hz, 2H), 2.79 (s, 3H); LC/MS (m/z) [M+1]+ 450.4 (calculated for C20H22F3N7O2, 449.18). Elem. Anal. Calc.: C, 45.99; H, 4.63; N, 18.77; Cl, 13.57. Found: C, 45.97; H, 4.40; N, 18.60; Cl, 12.39. Karl Fischer % water, 1.42. One mole free base contains 1.83 mol HCl and 0.41 mol water.

Provenance & Evidence