反应详情

A solution of 2-(2-Azido-1,1-difluoro-ethyl)-6-methyl-pyridine (700 mg, 3.54 mmol), as prepared in the preceding step, in MeOH (10 mL) was treated with 10% Pd/C (150 mg) under 39 Psi H2 atmosphere overnight. The reaction mixture was filtered through a pad of celite and the filtrate was evaporated to afford the product as a brown oil (605 mg, 99%). 1H NMR (CDCl3) δ 7.69 (t, J=7.74 Hz, 1H), 7.46 (d, J=7.70 Hz, 1H), 7.22 (d, J=7.81 Hz, 1H), 3.42 (t, J=14.40 Hz, 2H), 2.58 (s, 3H); LC/MS (m/z) [M+1] 173.2 (calculated for C8H11F2N2, 173.1).

1. filtrationThe reaction mixture was filtered through a pad of celite
2. customthe filtrate was evaporated