反应详情

温度

105 °C

Fumaric acid diethylester (21.6 g; 0.126 mol) is dissolved in toluene (900 ml) and heated at 105° C. A mixture of N-benzylglycine (25 g; 0.151 mol) and paraformaldehyde (25.36 g; 0.844 mol) is added in 4 g portions to the refluxing solution. After completion of the addition the mixture is heated for 18 h at 105° C. The mixture is then evaporated to dryness and suspended in n-hexane. The insoluble material is filtered off and the remaining solution is evaporated to dryness. The crude product is used for the next step without further purification. Yield: 32.5 g (70.3%), ESI-MS: m/z=306 [M+H]+

1. additionis added in 4 g portions to the refluxing solution
2. additionAfter completion of the addition the mixture
3. temperatureis heated for 18 h at 105° C
4. customThe mixture is then evaporated to dryness
5. filtrationThe insoluble material is filtered off
6. customthe remaining solution is evaporated to dryness
7. customThe crude product is used for the next step without further purification