Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-(1,1-Dimethylethyl) 3-ethyl (3R,4R)-4-[[(4-chlorophenyl)amino]carbonyl]-1,3-pyrrolidinedicarboxylate | HCID 69047627 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | HCID 69651958 | HCID 69651958 | — |
Reaction Steps
The ester obtained from step 2a (4.07 g; 10.3 mmol) is dissolved in a mixture of THF/water (1:1; 40 ml). LiOH monohydrate (0.947 g; 22.6 mmol) is added to the mixture and complete saponification is obtained after stirring for 18 h at 25° C. The mixture is acidified with 1N aq. HCl and diluted with ethyl acetate (100 ml). The organic phase is washed with brine (100 ml) and dried over Na2SO4. The organic phase is filtered and the filtrate is evaporated to dryness. Yield: 3.28 g (86.7%), ESI-MS: m/z=367 [M−H]−, Cl-pattern
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07550487B2 |
|---|
| Source dataset | uspto-grants-2009_06 |
|---|
| ORD ID | ord-c78f9c228a384773ae52d0358cf2bec3 |
|---|
| Source note | uspto-grants-2009_06 |
|---|
