Diisopropylethylamine → HCID 44249374, compound

Participants

Reaction Conditions

Reaction Steps

Compound 7a (1.85 g; 6 mmol) is suspended in acetonitrile (20 ml) and N,N-diisopropyl ethyl amin (1.65 ml; 10 mmol) is added at 25° C. BOP-CL (2.46 g; 10 mmol) is added as a solid and after stirring for 30 min at 25° C. 1-(4-amino-3-fluoro-phenyl)-1H-pyridin-2-one (1.45 g; 7 mmol) is added to the reaction mixture. The mixture is stirred for 4 d at 25° C., evaporated to dryness and dissolved in ethyl acetate (200 ml). The organic phase is washed with 2 N HCl (50 ml), with 10% aqueous Na2CO3 solution, water and brine and dried over Na2SO4. The organic phase is filtered and the filtrate is evaporated to dryness. The crude product is purified by silica gel chromatography. Yield: 1.77 g (58.1%), ESI-MS: m/z=472 [M−H]−

Provenance & Evidence